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The work was important, they thought, because such reversed cells, which have never existed in nature, could shed light on the origins of life and make it easier to create molecules with therapeutic value, potentially tackling significant medical challenges such as infectious disease and superbugs. But doubt crept in.
“It was never one light bulb moment. It was kind of a slow boiling over a few months,” Adamala, a synthetic biologist, said. People started asking questions, she added, “and we thought we can answer them, and then we realized we cannot.”
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